Contraline & Population Council Announce Option-to-License Agreement for a Revolutionary Male Contraceptive

Contraline is poised to advance the NES/T Gel, a groundbreaking late-stage male contraceptive

CHARLOTTESVILLE, Va.--(BUSINESS WIRE)-- Contraline, Inc., a clinical-stage biotechnology company, proudly announces the signing of an exclusive option-to-license agreement with the Population Council for the Nestorone/Testosterone Transdermal Gel (NES/T) for male contraception. Upon exercising the option, Contraline will spearhead the global development and commercialization of NES/T, positioning Contraline as the world’s preeminent biotechnology company in male contraception. Contraline’s pipeline now includes two revolutionary, clinical-stage, investigational male contraceptives: NES/T, a daily-use topical gel, and ADAM™, an implantable, reversible device.

NES/T is an investigational short-acting, transdermal, and reversible hormonal contraceptive, developed by the Population Council and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the US National Institutes of Health. The NES/T gel, containing Nestorone® (segesterone acetate) and testosterone, is formulated for men to apply daily to their shoulders to decrease sperm production. Over 750 men have been dosed with NES/T across Phase 1 and 2 clinical trials, with preliminary data suggesting NES/T has the potential to be a highly effective male contraceptive with an acceptable side-effect profile.